Overview of Current 7-OH Regulations in the United States

Regulation of kratom and its alkaloids continues to evolve across the United States. One area receiving specific attention from lawmakers and health agencies is 7-hydroxymitragynine (7-OH), an alkaloid naturally present in kratom in very small amounts. Several states have enacted targeted restrictions on concentrated or synthetic forms of 7-OH, while others have implemented limits on allowable percentages within kratom products. A number of states and local jurisdictions also maintain full kratom bans, which inherently include natural 7-OH content.

States With Specific 7-OH Restrictions

A group of states has implemented rules that address concentrated, isolated, or synthetic 7-OH, or that set maximum thresholds for 7-OH content in consumer kratom products.

Florida

Florida issued an emergency rule classifying isolated and concentrated 7-OH as a Schedule I controlled substance. Under this rule, selling, possessing, or distributing isolated or highly concentrated 7-OH products is prohibited. The regulation focuses primarily on concentrated or synthetic forms associated with adverse health reports.

Colorado

Colorado law restricts kratom products to less than 2 percent 7-OH within the total alkaloid content. The state also bans synthetic kratom products, placing additional limits on chemically altered extracts.

Mississippi

Mississippi legislation prohibits synthetic kratom extracts and products containing high concentrations of 7-OH. The state also set a minimum purchase age of 21 for all other kratom products sold within its borders.

Texas

Beginning September 1, 2025, Texas will ban synthetic kratom products. The state also limits the 7-OH content of kratom items to less than 2 percent of the total alkaloid composition.

Arizona and Utah

Both Arizona and Utah restrict the sale of kratom products containing more than 2 percent 7-OH of the total alkaloid content. Products exceeding this limit cannot be legally sold within either state.

Kentucky

Kentucky classified 7-OH as a Schedule I substance. As a result, the sale and possession of 7-OH products—whether isolated or concentrated—is prohibited statewide.

States With Full Kratom Bans

Some states have enacted complete kratom prohibitions, meaning all kratom products are banned regardless of alkaloid levels. These bans include kratom in all forms and therefore also encompass the naturally occurring 7-OH present in the plant.

States Where All Kratom Is Prohibited

• Alabama

• Arkansas

• Indiana

• Louisiana

• Rhode Island (schedule to transition to a regulated market in April 2026)

• Vermont

• Wisconsin

• Washington, D.C

Localized Kratom Restrictions

In addition to state-level regulations, certain cities and counties have adopted their own prohibitions or limitations.

California

San Diego maintains a local ban on kratom products.

Colorado

Denver prohibits kratom products for human consumption, despite broader statewide regulations allowing certain products.

Florida

Sarasota County enforces its own kratom ban independent of statewide rules.

Summary

Kratom and 7-OH regulations in the United States vary significantly by state and municipality. Some regions focus specifically on concentrated or synthetic 7-OH, others limit permissible alkaloid percentages, and several have instituted full kratom bans. These laws continue to evolve, and businesses and consumers benefit from remaining informed about current requirements in their local jurisdictions.